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S05E01: Carly Summers
McNamara/Troy has relocated to Los Angeles, but Sean and Christian quickly discover they are merely small fishes in a big pond. With the help of a powerful Hollywood publicist, the duo get jobs as medical consultants on a night-time soap opera called Hearts ‘n’ Scalpels. Meanwhile, Christian becomes involved with an aging actress requiring surgery to save her career, and Sean crosses paths with a Hollywood agent with horrific wounds on his chest and the dominatrix who inflicted them on him.

S05E02: Joyce & Sharon Monroe
Julia visits Los Angeles and introduces Sean and Christian to her new lover: Olivia Lord. Meanwhile, Christian poses for Playgirl in an effort to eclipse Sean’s newfound fame, Sean dates his Hearts ‘n’ Scalpels co-star, and the doctors operate on rival Marilyn Monroe impersonators.

S05E03: Everett Poe
Sean grows disturbed by Olivia’s promiscuous daughter Eden, in particular her influence on Annie, after she comes to McNamara/Troy requesting a hymen restoration. Matt shows up in Los Angeles with baby Jenna in tow, desperate for cash and claiming he has left Kimber. Sean discovers Kate’s secret. Christian hits a new low. Liz questions Julia and Olivia’s relationship.

S05E04: Dawn Budge II
Christian encounters a nun requesting a breast reduction, and a disturbed woman who requests his services as an escort to fulfill her dangerous fantasies. Sean tries to make Julia see Eden’s manipulation of Annie. Dawn Budge returns and requires surgery after an eagle attacks her face while hang-gliding. Sean and Christian are unwilling to fulfill her dream of visiting the Hearts ‘n Scalpels set until she falls victim to a serial sex attacker known as The Ass Bandit and worry about her suing them.

S05E05: Chaz Darling
Eden blackmails Christian into performing surgery on her friend. Sean acts out his sexual desires on Kate, but can’t deal with her own fantasies. Kimber appeals for help from her old porn manager when she and Matt fall on hard times and can’t afford the crystal meth they’re craving.

S05E06: Damien Sands
Christian encourages Sean to film a reality show pilot entitled Plastic Fantastic, allowing cameras to film their every move. But both soon realize that audiences would be more interested in their crazy personal lives than their surgical cases. Meanwhile, Julia and Liz face off against one another when Liz’s romantic interest in Olivia is revealed.

S05E07: Dr. Joshua Lee
Sean rediscovers his youth through his relationship with Eden and his friendship with Hearts ‘n’ Scalpels star Aidan Stone. Julia and Olivia question their relationship after they are both kidnapped by a carjacker. Kimber promises to dump Matt in return for surgery to repair her meth-destroyed face. An elderly doctor comes to McNamara/Troy requesting surgery to remove an alien chip from his back.

S05E08: Duke Collins
As Christmas approaches, Sean finally discovers the truth about Christian and Julia’s relationship. Matt bonds with his burns counselor in hospital following the explosion. Kimber and Ram announce their marital plans. Eden plots revenge on Julia. A mall Santa comes to McNamara/Troy requesting surgery on the bullet wound in his face. A group of Christmas carollers offer their services to the doctors in return for surgery.

S05E09: Rachel Ben Nattan
Sean hires Gina as McNamara/Troy’s new receptionist to get back at Christian. Christian finds his fidelity tested when Julia falls sick. Matt accompanies Rachel through surgery to remove body debris of the terrorist who blew up near her years ago. Sean finds himself haunted by Rachel’s suicide bomber. Dawn Budge is angered when Freddy makes plans to ride on a float at Gay Pride, and she later requires surgery when a lesbian biker rides into her face.

S05E10: Magda and Jeff
With help from his over-friendly new agent, Sean finds himself promoted to the lead character in Hearts ‘n’ Scalpels after a sex tape scandal forces Aidan to enter rehab. Christian rejects Gina’s advances as she guides him through a new form of sex. An elderly woman comes to McNamara/Troy requesting surgery on her much-younger husband.

S05E11: Kyle Ainge
Christian pieces together his and Wilber’s lives following Gina’s death, and faces off against Wilber’s kindergarten teacher, who has a fetish for biting the children in her care. Colleen reveals her true colors when a rival agent shows interest in representing Sean. A couple comes to McNamara/Troy for skin reconstruction following an accident on honeymoon which drove them to cannibalism in an effort to survive.

S05E12 -Lulu Grandiron
Christian becomes involved with a group of society women who all request surgery, including one who wishes to look like a cat. Sean worries about Colleen’s sanity, and Bliss exposes her for who she really is. Kimber and Ram invite another person into their marriage: Eden.

S05E13: August Walden
Sean confronts a television critic who criticized his acting in a magazine. Olivia returns from New York and helps Julia work out what is wrong with her, leading Julia to confront Eden. Matt and Rachel’s relationship falls apart, and Matt seeks solace with a young woman with a devastating reason for visiting Los Angeles.

S05E14: Candy Richards
Sean fears for his life when Colleen escapes from the psych ward and threatens to kill him. Christian reunites with an old flame. Matt tries to come to terms with sleeping with his own sister. Julia is rushed to hospital following the shooting. A deluded starlet comes to McNamara/Troy requesting surgery to fix her botched makeover.